- Identification and Application of Biomarkers in Molecular and Genomic Epidemiologic Research.
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Kyoung Mu Lee, Sohee Han, Woong Yang Park, Daehee Kang
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J Prev Med Public Health. 2009;42(6):349-355.
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DOI: https://doi.org/10.3961/jpmph.2009.42.6.349
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 Abstract
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- Biomarkers are characteristic biological properties that can be detected and measured in a variety of biological matrices in the human body, including the blood and tissue, to give an indication of whether there is a threat of disease, if a disease already exists, or how such a disease may develop in an individual case. Along the continuum from exposure to clinical disease and progression, exposure, internal dose, biologically effective dose, early biological effect, altered structure and/or function, clinical disease, and disease progression can potentially be observed and quantified using biomarkers. While the traditional discovery of biomarkers has been a slow process, the advent of molecular and genomic medicine has resulted in explosive growth in the discovery of new biomarkers. In this review, issues in evaluating biomarkers will be discussed and the biomarkers of environmental exposure, early biologic effect, and susceptibility identified and validated in epidemiological studies will be summarized. The spectrum of genomic approaches currently used to identify and apply biomarkers and strategies to validate genomic biomarkers will also be discussed.
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Citations
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Barbara Kossowska, Ilona Dudka, Roman Gancarz, Jolanta Antonowicz-Juchniewicz
International Journal of Hygiene and Environmental Health.2013; 216(1): 1. CrossRef - The vanishing zero revisited: Thresholds in the age of genomics
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- High Throughput Genotyping for Genomic Cohort Study.
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Woong Yang Park
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J Prev Med Public Health. 2007;40(2):102-107.
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DOI: https://doi.org/10.3961/jpmph.2007.40.2.102
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3,243
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Abstract
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- Human Genome Project (HGP) could unveil the secrets of human being by a long script of genetic codes, which enabled us to get access to mine the cause of diseases more efficiently. Two wheels for HGP, bioinformatics and high throughput technology are essential techniques for the genomic medicine. While microarray platforms are still evolving, we can screen more than 500,000 genotypes at once. Even we can sequence the whole genome of an organism within a day. Because the future medicne will focus on the genetic susceptibility of individuals, we need to find genetic variations of each person by efficient genotyping methods.
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Summary
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Citations to this article as recorded by - A novel protein chip for simultaneous detection of antibodies against four epidemic swine viruses in China
Yue Wu, Xudan Wu, Jing Chen, Jingfei Hu, Xiaobo Huang, Bin Zhou
BMC Veterinary Research.2020;[Epub] CrossRef - Detection and Differentiation of Four Poultry Diseases Using Asymmetric Reverse Transcription Polymerase Chain Reaction in Combination with Oligonucleotide Microarrays
Qimeng Tao, Xiurong Wang, Hongmei Bao, Jianan Wu, Lin Shi, Yanbing Li, Chuanling Qiao, Samuilenko Anatolij Yakovlevich, Poukhova Nina Mikhaylovna, Hualan Chen
Journal of Veterinary Diagnostic Investigation.2009; 21(5): 623. CrossRef
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